Biofunctionalisation of Si, GaAs and Au
We investigate molecular surface coatings of various material systems such as metal, silicon and III-V-semiconductors (InAs/GaAs/AlGaAs) in particular regarding their functionality in physiologic electrolytes for bio-sensing applications. This concerns, e.g., functional coatings of Au electrodes with diluted monolayers of DNA oligonucleotides as well as self-assembled monolayers (SAM) on GaAs/AlGaAs based field effect transistors. Besides a passivation of the substrate (biocompatibility) certain molecular layers allow the functionalization with, e.g., specific affinity receptors for the detection of proteins. In the case of the III-V semiconductor system, mercaptobiphenyl SAMs are being employed in collaboration with the group Tanaka (TUM biophyics). They will serve as a basis for establishing more complex hybrid systems with, e.g., lipid membranes or living cells. The work is financed by the DFG via Sonderforschungsbereich SFB563 and in part by the Fujitsu Laboratories of Europe.
